Abstract
In patients with a muscle disease a cellular hypersensitivity to muscle tissue was found by a direct macrophage migration inhibition test. In polymyositis the migration inhibition seems to parallel the severity of the disease. This sensitivity of lymphocytes to muscle antigen was also found in patients with a muscular dystrophy as well as in carriers. No arguments could be reported for a neural factor in muscular dystrophy. The result in myasthenia gravis varied and only a slight sensitisation has been shown. It is argued that this cellular hypersensitivity often has no role in pathogenesis, perhaps except in polymyositis. Probably this mmi-method can be used in genetic counseling in muscular dystrophy.
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