Abstract
A cellular hypersensitivity was found in patients with various kinds of diseases of the central or peripheral nervous system. A direct macrophage migration inhibition test was used in which the mixed lymphocyte reaction between lymphocytes in the peritoneal exudate cell suspension and human lymphocytes was abolished by γ-irradiation of 100 rad for at least 18 hours. The results were in favor of the hypothesis that these cellular immune reactions, even in multiple sclerosis and polyradiculoneuritis, are a secondary event occurring as the result of all kinds of nervous tissue damage. It is suggested that in multiple sclerosis a suppression of cellular immunity is also present.
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