Abstract
(Cell Host & Microbe 6, 563–569; December 17, 2009) In the Summary of the above article, the phrase in the third sentence “but not other ligases with siRNA, or a specific inhibitor” should have been deleted. The correct sentence reads, “RNA silencing of human DNA ligase I expression and a small molecule inhibitor of human DNA ligase I severely reduced replication of viral DNA in cells infected with VACV ligase-deficient mutants, indicating that the cellular enzyme plays a complementary role.” Any inconvenience caused by this error is regretted. This has been corrected in the original article online. Cellular DNA Ligase I Is Recruited to Cytoplasmic Vaccinia Virus Factories and Masks the Role of the Vaccinia Ligase in Viral DNA ReplicationParan et al.Cell Host & MicrobeDecember 17, 2009In BriefVaccinia virus (VACV) encodes DNA polymerase and additional proteins that enable cytoplasmic replication. We confirmed the ability of VACV DNA ligase mutants to replicate and tested the hypothesis that cellular ligases compensate for loss of viral gene expression. RNA silencing of human DNA ligase I expression and a small molecule inhibitor of human DNA ligase I severely reduced replication of viral DNA in cells infected with VACV ligase-deficient mutants, indicating that the cellular enzyme plays a complementary role. Full-Text PDF Open Archive
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