Abstract
Ventricular remodeling is related to the renin-angiotensin-aldosterone system, immune system, and various cytokines involved in inflammation, apoptosis, and cell signal regulation. Accumulated studies have shown that traditional Chinese medicine can significantly inhibit the process of ventricular remodeling, which may be related to the mechanism mentioned above. Here, we conducted a system overview to critically review the cellular and molecular mechanism of traditional Chinese medicine on ventricular remodeling. We mainly searched PubMed for basic research about the anti-ventricular remodeling of traditional Chinese medicine in 5 recent years, and then objectively summarized these researches. We included more than 25 kinds of Chinese herbal medicines including Qi-Li-Qian-Xin, Qi-Shen-Yi-Qi Pill, Xin-Ji-Er-Kang Formula, and Yi-Qi-Wen-Yang Decoction, and found that they can inhibit ventricular remodeling effectively through multi-components and multi-action targets, which are promoting the clinical application of traditional Chinese medicine.
Highlights
Ventricular remodeling, referring to a variety of injuries that change the original substances and cardiac morphology of the heart, is an adaptive response of the body and a pathophysiological process of lesion repair, overall ventricular compensation, and secondary pathophysiology [1]
Ventricular remodeling is a process of a series of morphological and structural changes in cardiomyocytes, collagen grids, and vascular beds, which is the basic mechanism of heart failure, so it is of great significance to study the pathogenesis of ventricular remodeling (VR) for the prevention and treatment of heart failure
Perhaps we can speculate the multiple mechanisms of antiVR from the same components of different traditional Chinese medicine (TCM), but we do not know whether the previous interactions of different TCM have changed the structure of the active components of TCM, which requires us to further improve the basic research of TCM against VR
Summary
Ventricular remodeling, referring to a variety of injuries that change the original substances and cardiac morphology of the heart, is an adaptive response of the body and a pathophysiological process of lesion repair, overall ventricular compensation, and secondary pathophysiology [1]. Through upregulating the expression of neuregulin-1, Qi-Li-Qiang-Xin can activate the PI3K/Akt signal pathway, promote Akt phosphorylation, stimulate the expression of vascular growth factor, and activate the anti-apoptosis protein, leading to the inhibition of the proportion of Bax/Bcl-2 and the expression of Caspase-3 [36]. Qi-ShenYi-Qi pills can inhibit the expression of CTGF protein and mRNA by regulating the TGF-β1/CTGF pathway and reducing the myocardial collagen deposition, leading to the improvement of VR on experimental autoimmune myocarditis rats [92]. (Maidong), can significantly reduce the experimental cardiac remodeling by improving hemodynamics and inhibiting the activation of RAAS It can reduce the production of ET-1 and the contents of Ang II, aldosterone, and hydroxyproline, and down-regulate the expression of AT1R, TNF-α, and TGF-β1 [113]. Due to the lack of sufficient experimental data, we do not yet understand the mechanism of TCM suppressing PPARγ and PGC-1α
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
