Abstract
Cells are the fundamental building blocks of life. Changes within a cell can propagate throughout much larger, more complex systems. Understanding how these changes arise internally within a cell and how cellular signals are transmitted through larger systems of cells, whether those systems be an organ, organism or a larger environmental assemblage, are critical, for example, to understanding how diseases arise and spread and how cells communicate and coordinate their actions. Microfluidic devices provide unique platforms from which to study many of these intra- and intercellular processes. The architectures enabled by microfluidic fabrication methods are on length and volume scales suitable for the sorting, transport, capture, culturing and analysis of single cells and small assemblages of cells. In addition, the secretions from cultured cells or cell lysates from cells transported and lysed in these devices are not significantly diluted prior to detection and so the minute quantities of species secreted...
Published Version
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