Abstract
CELLPEDIA is a repository database for current knowledge about human cells. It contains various types of information, such as cell morphologies, gene expression and literature references. The major role of CELLPEDIA is to provide a digital dictionary of human cells for the biomedical field, including support for the characterization of artificially generated cells in regenerative medicine. CELLPEDIA features (i) its own cell classification scheme, in which whole human cells are classified by their physical locations in addition to conventional taxonomy; and (ii) cell differentiation pathways compiled from biomedical textbooks and journal papers. Currently, human differentiated cells and stem cells are classified into 2260 and 66 cell taxonomy keys, respectively, from which 934 parent–child relationships reported in cell differentiation or transdifferentiation pathways are retrievable. As far as we know, this is the first attempt to develop a digital cell bank to function as a public resource for the accumulation of current knowledge about human cells. The CELLPEDIA homepage is freely accessible except for the data submission pages that require authentication (please send a password request to cell-info@cbrc.jp).Database URL: http://cellpedia.cbrc.jp/
Highlights
The human body consists of more than 10 trillion cells that have highly diverse structures and functions and play specific physiological roles [1]
One example is ‘fibroblasts’, which are found in multiple tissues but are known to have different characteristics, such as cell differentiation capacities, depending on their lineages and surrounding conditions [3]
It is recently reported that only a particular group of sinusoidal endothelial cells in the bone marrow with distinct gene expression patterns regulate the properties of hematopoietic stem cells [5]
Summary
The human body consists of more than 10 trillion cells that have highly diverse structures and functions and play specific physiological roles [1]. With the improved taxonomy as its backbone, CELLPEDIA provides a repository for cell image, gene expression and cell differentiation data, serving as a digital dictionary of human cells for the biomedical field.
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