Cell-Based Therapy for Schizophrenia: Can Mesenchymal Stem Cells do the Needful?

Abstract

We present an analysis of three patients from literature with a malignancy treated with high-dose chemotherapy and hematopoietic stem cell transplantation. It is evident that schizophrenia can be transferred during the cell graft from a schizophrenic donor, cured by the graft from a healthy donor, or cured by high-dose therapy and an autologous graft. We suggest that the use of allogeneic MSCs from healthy donors (including MSCs soluble and insoluble paracrine factors) in schizophrenia patients may be an exciting therapeutic option for further exploration.