Abstract
Our current understanding of induced pluripotent stem (iPS) cell generation has almost entirely been shaped by studies performed on reprogramming fibroblasts. However, whether or not the resulting model universally applies to the reprogramming process of other cell types is still largely unknown. By functionally and molecularly characterizing the reprogramming pathways of fibroblasts, neutrophils and keratinocytes, we unveil that while some aspects of the reprogramming process are conserved, the key events, including loss of original cell identity, mesenchymal to epithelial transition, the extent of developmental reversion and reactivation of the pluripotency network are to a large degree cell type specific. Thus we reveal universal and cell type specific features of the reprogramming process.
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