Abstract
Cell transplantation: relevance in understanding brain development and prospects in brain repair
Highlights
Neurodegenerative disorders such as Parkinson’s diseases (PD) and Huntington’s diseases (HD), neuronal injuries following trauma and neuronal cell death following strokes are major debilitating affections that are often accompanied by motor and cognitive dysfunctions with limited treatment options
Cell transplantation therapies have been considered for the last three decades as a serious avenue to explore with the ultimate aim to replace lost neurons with “new ones” initially originating from fetal neuroblasts and recently deriving from various sources of stem cells
This came as an evidence when attempts of cell therapy was undertaken with the use of human fetal neuroblasts or porcine fetal neuronal tissue for a time envisaged as a potential useful cell source for xenotransplantation in the human brain
Summary
Neurodegenerative disorders such as Parkinson’s diseases (PD) and Huntington’s diseases (HD), neuronal injuries following trauma and neuronal cell death following strokes are major debilitating affections that are often accompanied by motor and cognitive dysfunctions with limited treatment options. Cell transplantation therapies have been considered for the last three decades as a serious avenue to explore with the ultimate aim to replace lost neurons with “new ones” initially originating from fetal neuroblasts and recently deriving from various sources of stem cells.
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