Abstract
Cell surface antigens of normal urinary bladder epithelium (NBE) and bladder cancers of inbred ACI/N rats were assayed by antisera raised in rabbits. Mixed hemadsorption test combined with absorption analysis defined three kinds of cell surface antigens in both NBE and bladder cancer cells; the first antigen was common to lymphoid cells, the second was present in most of the epithelia, and the third was unique to NBE and present to a lesser extent in bladder cancers. In addition, bladder cancers had a fourth antigen that was common only to epidermis. These findings were confirmed by the use of typing sera for the third and the fourth antigens, which were prepared by absorptions of each antiserum with lymphoid cells and the lung. Direct titration of the typing sera against various cells revealed that the third antigen (NBE antigen) was species-specific and the fourth antigen (BC-SK antigen) was not common to human bladder cancers but common in part to mouse epidermal cells and bladder cancers.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
