Abstract
Cell Proliferative and Cell Cycle Effects of Atrazine Using Human Breast Cell Lines
Highlights
Breast cancer is the most frequent cancer among women, and it impacts 2.1 million women each year [1]
This study examined the effect of low level/environmentally relevant concentrations of atrazine on two breast cell lines (MCF-7, an estrogen responsive breast cancer cell line and MCF-10A, a non-cancerous human breast epithelial cell line) by studying cytotoxicity, proliferation and cell cycle events
Since endocrine disruptors like ATR act like natural hormones which are available in low doses, this study explored the effect of low level/ environmentally relevant concentrations of ATR on two human breast cell lines (MCF-7, an estrogen responsive breast cancer cell line and MCF-10A, a non-cancerous human breast epithelial cell line) by studying cytotoxicity and cell cycle events
Summary
Breast cancer is the most frequent cancer among women, and it impacts 2.1 million women each year [1]. It is estimated that 627,000 women died from breast cancer (approximately 15% of all cancer deaths in women) in 2018 [1]. The etiology of breast cancer has been linked to several factors including family history/ hereditary of BRCA1 and BRCA2 genes, hormone replacement therapy, obesity and alcohol [3,4,5]. Studies have shown that ovarian hormones, including estrogen and progesterone, may increase breast cancer risk by affecting rates of cell proliferation in the breast or by supporting enhanced cellular growth induced by estrogen dependent tumors [6]. Exposure to environmental pollutant including endocrine disruptors chemicals (EDC) have been implicated as potential risk factor in developing breast tumors [7]
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