Abstract
The mechanism of the lytic event in cell-mediated lympholysis is as yet incompletely understood. Two major hypotheses have been proposed: (1) lysis is a nonspecific result of the intimacy created between killer and target by specific antigen-receptor binding, and (2) lysis is effected by the killer cell receptor itself or by a closely linked cell surface component. Two populations of cytotoxic effector cells were coincubated, one relevantly sensitized to the second and the second irrelevantly sensitized to a third party; in some experiments the third party cells were also added. If target cell lysis occurred because of killer-target intimacy, the relevantly sensitized killers should have been lysed when incubated with cytotoxic targets. Relevantly sensitized killers were not lysed when coincubated with either cytotoxic targets alone or with cytotoxic targets and their appropriate third party targets. These findings suggest that the lytic event in cell-mediated lympholysis is accomplished by the receptor itself, or by a geographically closely linked cell surface component.
Published Version
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