Abstract
Triple-negative breast cancer (TNBC) is a highly malignant tumor histotype which lacks effective targeted therapies, thereby being considered as the most aggressive form of breast carcinoma. To identify novel compounds which could counteract TNBC cell growth, we explored the in vitro effects of crude extracts and <10 kDa-filtered fractions of the coelomic fluid obtained from the sea urchin Arbacia lixula on TNBC MDA-MB231 cells. We examined cell viability, cycle distribution, apoptotic/autophagic activity, and mitochondrial polarization/cell redox status. Here, we report the first data demonstrating an anti-TNBC effect by A. lixula-derived coelomic fluid extracts. Thus, identification of the water-soluble bioactive component(s) contained in the extracts deserve(s) further investigation aimed to devise novel promising prevention and/or treatment agents effective against highly malignant breast tumors.
Highlights
Sea urchins are invertebrates belonging to the class Echinoidea, which incorporates more than 700 described extant species worldwide
The chemical components of such machineries can be beneficial to drug design due to their interactions with some selected proteins that have been conserved during the evolution and whose human orthologues are likely to be implicated in different pathobiological processes which control disease development, e.g., cell proliferation and death or immune and inflammatory responses [5]
The aim of our study was to explore the coelomic fluid (CF) extract-mediated effects, if any, on viability cell cycle distribution, apoptosis, autophagic activity, and mitochondrial polarization/cell redox state of cancer cells. We report that both crude extracts and
Summary
Sea urchins are invertebrates belonging to the class Echinoidea (phylum Echinodermata), which incorporates more than 700 described extant species worldwide They have been the object of growing interest as available sources of new biomolecules which, on the basis of their activity as antibacterial, antiviral, antiprotozoal, antifungal, and anticancer agents, may be potential candidates for drug discovery and development [1,2,3,4]. Li et al [6,7], in their study, reported for the first time the isolation and the chemical characterization of antimicrobial peptides (AMPs), named strongylocins 1, 2, and centrocins 1, 2, derived from the coelomocytes extract of the green sea urchin Strongylocentrotus droebachiensis. These peptides showed a significant antibacterial activity against both Gram-positive and Gram-negative bacteria
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