Abstract
The development of new biocompatible polymer substrates is still of interest to many research teams. We aimed to combine a plasma treatment of fluorinated ethylene propylene (FEP) substrate with a technique of improved phase separation. Plasma exposure served for substrate activation and modification of surface properties, such as roughness, chemistry, and wettability. The treated FEP substrate was applied for the growth of a honeycomb-like pattern from polystyrene solution. The properties of the pattern strongly depended on the primary plasma exposure of the FEP substrate. The physico-chemical properties such as changes of the surface chemistry, wettability, and morphology of the prepared pattern were determined. The cell response of primary fibroblasts and osteoblasts was studied on a honeycomb pattern. The prepared honeycomb-like pattern from polystyrene showed an increase in cell viability and a positive effect on cell adhesion and proliferation for both primary fibroblasts and osteoblasts.
Highlights
In 1991, an American research team led by Vacanti successfully implanted the first cells-seeded scaffold from a synthetic polymer to the human body [1]
The application of the poly-L-lactic acid (PLLA) layer had a positive the surface properties of the substrate, and the number of cells was significantly increased effect on the surface properties of the substrate, and the number of cells was significantly on the biopolymer microstructure compared to pristine fluorinated ethylene propylene (FEP) [54], in which we revealed that increased on the biopolymer microstructure compared to pristine FEP [54], in which we the PLLA pattern present on the treated FEP foil can be used for MRC-5 cell growth enrevealed that the PLLA pattern present on the treated FEP foil can be used for MRC-5 cell hancement
We have confirmed that the plasma exposure itself of perfluorethylenepropylene significantly improved the cytocompatibility for both studied cell lines
Summary
In 1991, an American research team led by Vacanti successfully implanted the first cells-seeded scaffold from a synthetic polymer to the human body [1]. Many research studies on this topic are published every year and have shown how artificial polymer substrates are promising candidates in tissue engineering [2]. The essential characteristics of the polymer scaffold are biocompatibility, high porosity with suitable pore array, high surface area, appropriate mechanical strength, and positive cell interaction (adhesion, proliferation, and differentiation) [3]. Several techniques for surface optimization of materials, such as laser and plasma treatment, ion implantation, and carbon and metal nanoparticle grafting, and their positive effects on cell growth have been described [4,5,6]. Crucial surface characteristics regulating cell behavior have been discussed, mainly, surface chemistry, wettability, energy, morphology, roughness, electrical charge, and conductivity [7]
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