Abstract
Dextran/Sulfodextran-graft-polyacrylamide- and polyacrylamide-based hydrogels were synthesized by radical polymerization and loaded with cefuroxime to obtain antimicrobial wound dressings. Antibiotic release from the antibiotic-loaded hydrogels into an aqueous solution was studied by the HPLC-UV method. It is shown that cefuroxime-loaded Dextran/Sulfodextran-graft-polyacrylamide hydrogels release the antibiotic more slowly compared to polyacrylamide hydrogel with the same density of cross-links. Antibacterial activity of the synthesized materials was tested in vitro against wild strains of S. aureus, E. coli, and Klebsiella spp. The possibility of using the obtained antimicrobial hydrogels for the treatment of infected wounds was confirmed in vivo in a rat model.
Highlights
Among the many antibacterial agents, antibiotics are the most effective and widely used drugs
Our idea was to create polyacrylamide-based antimicrobial hydrogels for the treatment of infected wounds. These hydrogels can be loaded with the desired amount of antibiotics, and their local application for drug release provides overcoming the side effects of a systemic overdose
As shown earlier [18], the number of grafted polyacrylamide chains in the synthesized D(SD)-g-PAA copolymers is determined by the molar ratio of the polysaccharide and
Summary
Among the many antibacterial agents, antibiotics are the most effective and widely used drugs Their widespread and often thoughtless use has provoked the emergence and expansion of resistant strains of bacteria. Over the last few decades, various antibiotic-loaded hydrogels have been developed as antibacterial coatings and dressings for the treatment of superficial trauma, burn, or diabetic wounds [1,2,3,4,5]. These materials release antibiotics at the wound site, preventing infection and promoting the healing process [6]. Local administration of antibiotics significantly reduces the unwanted side effects that are often observed with systemic use
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