Abstract
The development of antibiotic resistance in bacteria possesses a huge threat to public health by nullifying the effect of even the most efficient antibiotics. From years, LDHs type nanomaterials have been used as drug carriers for a wide variety of pharmaceutically active molecules due to their delivery properties, making these inorganic-organic nanohybrids very efficient antimicrobial agents. The major purpose of this work was to synthesize and characterize ceftriaxone intercalated layered nanostructures for further use to treat some infections, mostly of them child infections. The novel nanohybrid materials were prepared by ion exchange route and coprecipitation method. Structural and morphological characterization was performed by FTIR, EDX and SEM techniques. The results revealed a high incorporation of the drug in the interlayer space of promising nanostructures.
Highlights
The development of antibiotic resistance in bacteria possesses a huge threat to public health by nullifying the effect of even the most efficient antibiotics
Layered double hydroxides (LDHs) nanoparticles can be used as drug carriers due to their ability of modifying surface and size distribution in order to reduce the risk of toxic side effects by targeting specific cells or tissues
A great advantage of these nanomaterials is that the metal cations can be substituted by others such as Fe, Zn, Co, Mn, Ni and Co, Cr, V, Ga and the interlayer anions can be replaced by a wide variety of inorganic or organic anions [4-16]
Summary
Layered double hydroxides (LDHs) nanoparticles can be used as drug carriers due to their ability of modifying surface and size distribution in order to reduce the risk of toxic side effects by targeting specific cells or tissues. These biocompatible inorganic materials possess a higher stability and lower toxicity than other drug delivery systems [1-3]. Ceftriaxone, a third generation cephalosporin, is used to treat severe infections such as community-acquired pneumonia, gonorrhea and meningitis being a timedependent killer Intercalation of this antibiotic into LDHs structure
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
