Abstract

Due to the widespread presence of dopamine in living organisms and its physiological and pharmacological effects, developing rapid and sensitive methods for detecting dopamine has been of great significance. Fluorescent probes are a commonly used and highly sensitive detection method. In this work, based on a self-developed amphipathic polymer template, CdS/ZnS fluorescent quantum dots (QDs) with a maximum absorption wavelength of 500–550 nm were synthesized and characterized. They exhibited stable fluorescence in the pH range from weak acid to alkaline, and fluorescence quenching occurred at pH = 4.5. The QDs could be applied as fluorescent probes for detecting dopamine, with a limit of detection 0.027 mM and high selectivity, unaffected by common metal ions, amino acids, glucose, etc. Compared to the high activity of dopamine being oxidized easily, this fluorescent QDs and its template polymer PEI played a stabilizing role during the testing process. Therefore, this work provides a promising dopamine fluorescent probe with application prospects.

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