Abstract
Microtubule assembly is a critical cellular process that is tightly regulated in space and time via the universal microtubule nucleator, the gamma-tubulin ring complex (γTuRC). Despite being present throughout the cytoplasm, γTuRC's activity is restricted to specific sites including the centrosome and Golgi. To better understand how γTuRC is activated, we focused on a well-conserved γTuRC nucleation activator (γTuNA) domain within the centrosomal scaffold protein, Cdk5rap2, which has previously been reported to increase the number of microtubules generated by γTuRC.
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