Abstract
BackgroundCadherin-2 (CDH2) gene polymorphisms were reported to be associated with the induction and development of knee osteoarthritis (OA).MethodsThis case–control study was designed to explore the association between CDH2 gene rs11564299 polymorphism and the risk of knee OA in Chinese subjects. The polymorphism was genotyped by polymerase chain reaction and Sanger sequencing.ResultsG allele or GG genotype of CDH2 gene rs11564299 polymorphism was related to increased risk for knee OA in the Chinese Han population. Additionally, subgroup analyses indicated that the female, smoker, drinker, and BMI ≥ 25 kg/m2 groups showed increased risk for knee OA. Additionally, this polymorphism was associated with CRP and Kellgren–Lawrence grade.ConclusionIn summary, this current study reveals that CDH2 gene rs11564299 polymorphism is a risk factor for knee OA development in this Chinese population. The genotypes distribution differed significantly among OA patients and healthy controls and may be a useful tool in the evaluation of OA susceptibility in Chinese Han population.
Highlights
Cadherin-2 (CDH2) gene polymorphisms were reported to be associated with the induction and development of knee osteoarthritis (OA)
We have investigated the role of CDH2 rs11564299 polymorphism in the risk of OA stratified by age, sex, smoking, body mass index (BMI), and drinking (Table 3)
Our results indicated that AG, GG, and AG+GG genotype were more frequent in C-reactive protein (CRP) ≥ 25 mg/L compared to CRP < 25 mg/L and in patients with K-L grade III or IV compared to K-L grade II
Summary
Cadherin-2 (CDH2) gene polymorphisms were reported to be associated with the induction and development of knee osteoarthritis (OA). Osteoarthritis (OA) is one of the most common chronic joint diseases. It leads to diminished quality of life and even disability in the elderly worldwide. The radiographic definition for OA is according to the criteria of Kellgren–Lawrence (K/L) radiographic grading scheme This overall joint scoring system grades OA from 0 to 4 score, which defines OA by the presence of a definite osteophyte (grade ≥ 2), and the presumed successive appearance of joint space narrowing, cysts, sclerosis, and deformity were regarded as more severe grades. Studies showed many candidate genes including Cadherin 2 (CDH2) as susceptibility loci for OA in different ethnic groups
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
