Association of matrix Gla protein polymorphism and knee osteoarthritis in a chinese population.

Wenpeng Hui,Xiao Wang,Zhong Cao,Junfeng Zhu

doi:10.1042/bsr20182228

Abstract

Several studies have explored the association between matrix Gla protein (MGP) gene polymorphism and knee osteoarthritis (OA) risk; however, they obtained conflicting findings. The present study aims to explore the association of MGP gene polymorphism and OA risk in a Chinese Han population. A total of 256 patients with radiographic knee OA and 327 control subjects were recruited in this case–control study. The genotypes of MGP gene rs1800802 polymorphism was determined by standard PCR and restriction fragment length polymorphism (PCR-RLFP). In this case–control study, we observed that MGP gene rs1800802 polymorphism increased the risk of knee OA. Subgroup analyses also found that rs1800802 polymorphism was related to the elevated risk for knee OA among the female, smoker, drinker, and body mass index (BMI) ≥25 kg/m2 groups. In conclusion, this study shows that MGP gene rs1800802 polymorphism is associated with increased risk for knee OA in Chinese Han population and the rs1800802 polymorphism may be a diagnostic marker of radiographic knee OA.

Highlights

Osteoarthritis (OA), is the most prevalent type of arthritis and main reason for the chronic disability of the elderly [1]
matrix Gla protein (MGP) rs1800802 polymorphism conformed to the Hardy–Weinberg equilibrium (HWE)
Our results indicated that GG genotype had higher susceptibility to OA compared with AA genotype (GG vs AA; adjusted odds ratio (OR): 2.14; 95% confidence interval (CI): 1.05–4.36; P=0.035)

Summary

Introduction

Osteoarthritis (OA), is the most prevalent type of arthritis and main reason for the chronic disability of the elderly [1]. According to the WHO, at least 10% of people aged ≥ 60 years old worldwide suffer from OA, characterized by joint stiffness, limitation of movement, progressive loss of articular cartilage, and variable degrees of inflammation [2]. The main pathological changes include fibrillation, osteophytes, loss of articular cartilage, and subchondral bone sclerosis. Knee OA is a multifactorial disease, which may result from several factors, such as obesity, joint trauma, increasing aging trend, and excessive physical activity. Besides those environmental and individual factors, genetic component accounts for nearly up to 50% of the risk of OA development [3]. Certain gene studies may provide a novel potential insight and treatment strategy for OA development [4]

Methods

Results

Conclusion