Abstract
Tumor Immunology A subset of immune cells called conventional dendritic cell 1 (cDC1) has been shown to play a critical role in antitumor responses. Hubert et al. now show that human cDC1 contribute to antitumor responses through the production of type III interferon, also known as IFN-γ1. The authors analyzed primary breast tumors and publicly available transcriptomic data and pinpointed IFN-γ1 production by cDC1 as being associated with favorable patient outcomes and promoting a microenvironment with T helper 1 (TH1)–associated cytokines and chemokines. By treating breast cell tumor suspensions with a Toll-like receptor 3 agonist, they were able to induce TH1-polarized responses and IFN-γ1 production by cDC1. These findings provide insight into how cDC1 contribute to antitumor immunity and how they might be targeted for potential therapeutic strategies. Sci. Immunol. 5 , eaav3942 (2020).
Published Version
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