Abstract
Introduction Case 1 The patient is a 75-year-old, otherwise healthy male who had a history of developing a bilateral axillary ‘burning,’ with a painful, pruritic erythematous rash in bilateral axillae, right worse than left. The rash persisted for 2 months despite topical steroid treatment. Physical exam revealed an 8 4 cm pink tumor with erosion in the ight axilla. Biopsy of the right axillary tumor revealed mycosis funoides (MF) with large cell transformation (Figure 1A). There was a onfluent dermal mass of enlarged and atypical lymphocytes, with xocytosis of lymphocytes into the overlying atrophic epidermis. The arge lymphocytes contained vesicular chromatin and variably promnent nucleoli, representing 75% of the infiltrating lymphocyte poplation. Also present was a minor population of intermixed small ymphocytes with complexly folded nuclei and condensed nuclear hromatin. The large atypical lymphocytes were positive for CD3, D4, and CD30, and negative for CD8, anaplastic lymphoma ki-
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