Abstract
Purpose: Osteoarthritis (OA) is a progressive joint disease that is strongly associated with calcium-containing crystal formation (mineralization) by chondrocytes leading ultimately to joint calcification. However, this calcification process is poorly understood and treatments targeting underlying disease mechanisms lacking. CD11b integrin (CD11b/CD18, Mac-1, or αMβ2) is a member of the beta 2 integrin family of adhesion receptors, critically involved in the development of several inflammatory diseases, including collagen-induced arthritis, where CD11b-deficient mice exhibited increased cartilage degradation as compared with those of WT control animals.
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