CD10 expression by stromal cells in carcinoma of breast and its correlation with ER, PR, HER2neu and Ki67-A tissue microarray study in a tertiary care hospital

Abstract

Introduction: CD10 is a metalloproteinase (Zinc dependent) which is expressed in stroma of various epithelial malignancies. It is associated with biological aggressiveness of the tumor. Till now very few studies has been undertaken correlating CD10 with other prognostic markers like lymphnode status, tumor grade, stage, ER, PR, HER2-neu and ki67 in breast carcinoma. Aim: To see the CD10 expression in breast carcinoma and correlate it with ER, PR, HER2 neu and ki67. Materials and Methods: 55 cases of carcinoma breast were diagnosed on histology. Tissue microarray blocks were prepared and Immunohistochemistry was performed for ER, PR, HER2neu, Ki67 and CD10. Result: 32(58%) cases are CD10 positive and 23 (42%) cases are CD10 negative. Out of this 32 positive cases, 12 (22%) cases are weak positive and 20 (36%) cases are strong positive. CD10 is positively correlated with tumor grade.CD10 is negatively correlated with ER and PR status which is not statistically significant and no correlation is found between CD10 and HER2-neu. A positive correlation is seen between CD10 and ki67, but it is not statistically significant. Conclusion: CD10 expression is positively correlated with Ki67 and increasing tumor grade and whereas inversely correlated with ER and PR status. No correlation is seen between CD10 with lymph node status and HER2-neu. Keywords: Breast carcinoma, Histomorphology, IHC, Tissue microarray.