Abstract
CCR5 is a seven-transmembrane-spanning receptor for the CC chemokines: MlP-1α, MIP-1β, and RANTES that induce chemotaxis and activation of leukocytes. CCR5 is expressed on small populations of circulating human monocytes and effector/memory T-cells, and on microglial cells and brain capillary endothelial cells. CCR5 is a major coreceptor for the entry of HIV-1 into CD4+ cells. This chapter presents a study in which the CCR5–/– mice developed, grew and reproduced normally, and were not severely immunocompromised. CCR5 deficiency did not significantly affect lifespan. The CCR5-deficient mice exhibited small phenotypic differences from wild-type animals in assays of leukocyte migration and immune function. The CCR5-deficient mice are valuable in identifying the specific immune functions of this receptor in vivo, to determine whether it is involved in the pathogenesis of infiammatory, infectious and autoimmune diseases.
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