Abstract
The NR2 subunits serve as modulatory subunits that potentiate N-methyl-D-aspartate receptor-2C (NMDAR1) receptor activity in a heteromeric formation and confer a functional variability, depending on NR2 subunit composition. It is highly expressed in the cerebellar granule cells. This chapter presents a study in which the NR2C–/– single mutant and NR2A–/–NR2C–/– double mutant mice both developed and mated normally. They showed no histological changes in the cerebellum. The NMDA receptor-mediated components of EPSCs in granule cells were reduced in the NR2C-deficient mice and abolished in mice lacking both NR2A and NR2C. The NR2C–/– mice also showed normal movements in the motor coordination tasks tested. The NR2A–/–NR2C–/– mice can also manage simple coordinated tasks, but fail more challenging tasks such as staying on a rapidly rotating rod. NMDAR-2C plays a role in synaptic transmission in granule cells in the cerebellum.
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