Abstract
Introduction and aim: Antimikrobial peptides (AMP) are one of the most important component of innate immune system and have important role in many respiratory disease. No data is available in the literature about the levels of AMP in pediatric patients with non-CF bronchiectasis (BE). The aim of this study was to determine cathelicidin and defensin levels of bronchoalveolar lavage fluid (BAL) in non-CF BE pediatric patients and to compare with control group. Method: The patients between 0-16 years-old was admitted between 2012-2013 september and age and gender matched healthy controls were enrolled in the multi-center study. BAL samples of the patients were obtained with flexible bronchoscopy. As control, BAL was taken during operation of participants who had no lung disease and any other chronic disease. Cathelicidin (LL37) ve β2 defensin levels in BAL were determined with ELISA method. Findings: Sixty-seven non-CF BE patients, 57% of them were male, enrolled in the study. Median age was9.9±2.9 years. Thirty-eight children included to the study as control group and age and gender distribution were not statistically different between the two groups (p>0,05). Cathelicidin and beta 2 defensins were significantly higher in BE group compared with healthy controls (p Conclusion: This is the first study about AMP levels of pediatric non-CF BE patients. Cathelicidin and beta 2 defensin levels were significantly higher in pediatric BE patients. AMP may have important roles in immune systems of pediatric BE patients.
Published Version
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