Abstract
Abstract Context.—The association between aberrant (nuclear) β-catenin expression and cyclin D1 accumulation has been demonstrated in diverse neoplasms. In synovial sarcoma (SS), aberrant β-catenin expression has prognostic relevance, but the association with cyclin D1 has not been established. The SYT-SSX fusion protein, unique to SS, may independently increase cyclin D1. Objective.—To determine whether nuclear β-catenin is associated with cyclin D1 overexpression in SS and whether primary and metastatic SS differ in the expression of these markers. Design.—We incorporated 82 tumors initially diagnosed as SS into a tissue array. Fluorescence in situ hybridization with custom probes was used to select t(X;18) positive tumors. Clinical data, tumor type and outcome were tabulated. The tumors were tested for the association between nuclear β-catenin and cyclin D1 immunostaining. Primary and metastatic tumors were compared. Results.—Fifty-one tumors (41 primary and 10 metastatic) from 43 patients demonstrated...
Published Version
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