Abstract
The greater part of noradrenaline (NA) in sympathetic autonomic neurone is bound to specific storage particles. These particles, called “dense-cored vesicles” or “granular vesicles,” can be divided into two groups: (1) the large granular vesicles, which were observed in neuronal perikarya and in their axons and (2) small granular vesicles, which are most numerous in terminal varicosities. It has been proved that both types of these vesicles contain NA. The large granular vesicles contain adenosine triphosphate (ATP) and proteins—chromogranin A and dopamine-β-hydroxylase (DBH). Large granular vesicles do not serve as simple transport units of NA but they fulfill a sophisticated function. Their role is to supply the nerve terminals with DBH, membranes, and proteins. The presence of NA in these vesicles during passage in axons is incidental. It is not certain if small granular vesicles carry DBH and other constituents of the binding complex as the large vesicles.
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