CATCHR, HOPS and CORVET tethering complexes share a similar architecture.

Abstract

We show that the Saccharomyces cerevisiae GARP complex and the Cog1-4 subcomplex of the COG complex, both members of the complexes associated with tethering containing helical rods (CATCHR) family of multisubunit tethering complexes, share the same subunit organization. We also show that the HOPS complex, a tethering complex acting in the endolysosomal pathway, shares a similar architecture, suggesting that multisubunit tethering complexes use related structural frameworks.