Catalytic Enantioselective Synthesis of Trisubstituted Secondary Allylic Alcohols Starting from Terminal Alkynes and Aldehydes

Abstract

AbstractA general one‐pot method for the enantioselective synthesis of β,β‐disubstituted allylic alcohols has been developed starting from readily available terminal alkynes and aldehydes. Trisubstituted (E)‐vinylaluminium reagents, generated regio‐ and stereoselectively by the Zr‐catalyzed carboalumination of the alkynes with Me3Al, was used in subsequent enantioselective addition reactions with aldehydes using a DPP‐H8‐BINOL‐derived titanium catalyst system at low catalyst loading (5 mol‐%).