Abstract
One-pot procedure: A general method for the highly enantioselective synthesis of α-substituted allylic alcohols has been developed starting from readily available terminal alkynes and aldehydes and proceeding via vinylaluminum reagents (see scheme, dppp=1,3-bis(diphenylphosphino)propane). The use of Me2AlH is essential in the Ni-catalyzed hydroalumination step to generate vinylaluminum reagents that cannot reduce the aldehyde.
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