Case studies on the association of Iron Deficiency Anemia with Thrombocytopenia and Reactive Thrombocytosis

Abstract

Iron Deficiency Anemia (IDA) is the most prevalent blood disorder. Iron deficiency stands as a major cause for most of the anemia cases in the country. So, suggestions and efforts are being made to signify the importance of iron in regular diet and in the form of supplementation. Iron deficiency can be addressed effectively but when untreated it can lead to other severe disorders. Thrombocytosis and Thrombocytopenia are two interlinked related to iron deficiency in most cases. Literature suggests that Reactive thrombocytosis (RT) is common in patients with iron deficiency. This study focusses on the retrospective investigations and correlation of the relationship between the ferritin content, anemia, platelet counts and normalization of the same with iron supplementation. Out of the 165 patients, 72 were fit for the study after subjecting to the exclusion criteria of inflammatory diseases, infections, neoplasms etc. These 72 were segregated on the basis of the diagnosis of Thrombocytosis or Thrombocytopenia to establish proper correlation. 61 of 72 patients were diagnosed with thrombocytosis which constituted about 84.72% of the selected patients. 11 of 72 patients were diagnosed with thrombocytopenia. In this study it is clearly evident that both reactive thrombocytosis and thrombocytopenia are resultant of IDA. The platelet levels were elevated in many patients and in few their levels were lowered . The determining factor of platelets count is ferritin saturation. The changes in the iron saturation resulted in both elevation and depression in the platelet count. The platelet morphology lead to the changes in the platelet parameters. it can be advocated that both the conditions are rare and can occur concurrently in patients with IDA.