Case Report: Two Cases of Subacute Thyroiditis Following SARS-CoV-2 Vaccination.

Catherine Bornemann,Caroline Bouter,Katharina Woyk

doi:10.3389/fmed.2021.737142

Catherine Bornemann, Caroline Bouter + Show 1 more

Open Access

https://doi.org/10.3389/fmed.2021.737142

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Abstract

Subacute thyroiditis is an inflammatory thyroid disorder associated with viral infections. Rare cases of subacute thyroiditis have also been described following vaccination. Recently, a few cases of subacute thyroiditis following SARS-CoV-2 vaccination have also been reported. Here, we present two cases of cytological proven subacute thyroiditis after receiving the first dose of a SARS-CoV-2 vaccination. We describe clinical, laboratory, imaging and cytological findings in two cases of subacute thyroiditis that presented in our department 2 weeks after SARS-CoV-2 vaccination with Spikevax (Moderna Biotech, Spain) and Vaxzevria (AstraZeneca; Sweden). Both cases did not have a previous history of thyroid disorders and presented with anterior and lateral neck pain. Clinical test results as well as cytological findings were consistent with subacute thyroiditis. Subacute thyroiditis may develop following a SARS-CoV-2 vaccination and should be considered as a possible side effect in cases that present with thyroid pain.

Highlights

Subacute thyroiditis is an inflammatory thyroid disorder associated with viral infections
Subacute thyroiditis is a self-limiting benign thyroid disorder commonly associated with upper respiratory tract viral infection
Several viruses have been reported as possible agents in subacute thyroiditis including adenovirus, enterovirus, influenza virus, cytomegalovirus, rubella virus, Epstein Barr virus, Coxsackie virus, and measles virus [4]

Summary

Introduction

Subacute thyroiditis is an inflammatory thyroid disorder associated with viral infections. To several viruses that have been reported as possible causative agents in thyroiditis, the occurrence of subacute thyroiditis has been described following influenza or Hepatitis B vaccination [2,3,4,5,6,7,8]. Cases of subacute thyroiditis following SARS-CoV-2 vaccination with CoronaVac (Sinovac Life Sciences, China), Comirnaty (BioNTech, Fosun Pharma, Pfizer, Germany, and USA) and Vaxzevria (AstraZeneca; Sweden) have been described [5, 9,10,11,12].

Results

Conclusion