Abstract
A hydatidiform mole is a type of placental abnormality that is associated with gestational trophoblastic disease (GTD). It can be complete or partial mole. They are typically considered benign, but they are also premalignant, with the potential to become malignant and invasive to other organs (gestational trophoblastic neoplasia/GTN). Management of the hydatiform moles is curettage therapy and suction, which aims to therapy and diagnostic. Follow-up post evacuation of moles must be tight with serum hCG and clinical examination. When there is evidence of vaginal bleeding and an increase in serum hCG, chemotherapy must be used as an adjuvant. This case report intends to persuade clinicians that adjuvant therapy with chemotherapy combination-based Methotrexate/MTX and etoposide can recover and eliminate vaginal bleeding disorders. On her first pregnancy, a woman of 27 years old develops a complete hydatiform mole. The curettage and suction procedure were then performed twice. She also receives chemotherapy in three series of single MTX and three series of MTX plus Etoposide. Following this therapy, the patient recovers, normal hCG level and has no vaginal bleeding problems.
Highlights
The most frequently reported gestational trophoblastic disease (GTD) is hydatidiform mole (HM), a type of abnormal human pregnancy[1]
HM is a benign form, but it can be classified as premalignant because it has the potential to become malignant, metastasize and common cause of gestational trophoblastic neoplasia (GTN) [4]
The incidence has increased in women under the age of 20 and over the age of 40. It is greater in nulliparous women, a low-income country, as well as female patients whose diets are lacking in carotene, protein, and folic acid [6], uterine size up to 20 weeks, raising hCG levels above 100.000 mIU/mL, lutein cysts' presence, medical history of second pregnancy with mole, post evacuation hemorrhage, the existence of lungs involvement, and medical issues of preeclampsia, histopathological characteristics of excessive trophoblastic hyperplasia, and histopathological characteristics of intense trophoblastic hyperplasia [7]
Summary
The most frequently reported GTD is hydatidiform mole (HM), a type of abnormal human pregnancy[1]. The incidence has increased in women under the age of 20 and over the age of 40 It is greater in nulliparous women, a low-income country, as well as female patients whose diets are lacking in carotene, protein, and folic acid [6], uterine size up to 20 weeks, raising hCG levels above 100.000 mIU/mL, lutein cysts' presence, medical history of second pregnancy with mole, post evacuation hemorrhage, the existence of lungs involvement, and medical issues of preeclampsia, histopathological characteristics of excessive trophoblastic hyperplasia, and histopathological characteristics of intense trophoblastic hyperplasia [7]. Advantages, including to make a diagnosis HM, to assess post molar follow-up, to estimate cases which will go into spontaneous remission or, on the opposite, develop GTN, to control response to chemotherapy and surgical intervention, and to identify relapse situations [10]. The several regimens of chemotherapy that are commonly used for GTN treatment including MTX, actinomycin D, vincristine, cyclophosphamide, and etoposide
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