Abstract
Abstract- Fibrosarcomas are rare but highly fulminant and aggressively malignant neoplasm whichoccurs as a result of mutated spindle-shaped fibroblasts. According to WHO, they are soft tissuesarcoma commonly present seldom at cutis. The etiology of such a malignancy is obscurednevertheless it has several predisposing factors like pre-existing pathology but the commonest ofthem is radiation. Mesenchymal malignancies were initially over-diagnosed and were the epicenter ofdiagnostic dilemma to the pathologist, but with the advent of Vimentin staining andimmunohistochemistry, the diagnostic front has fairly advanced for fibrosarcomas. Incidence ofFibrosarcoma in Maxilla accounts for less than 0.1%, when compared to other head and neckmalignancies, and is predominantly found between 2nd to 6th decades of life. Various approacheshave been documented in the literature regarding its treatment, but aggressive surgical excisionremains the mainstay of treating Fibrosarcomas. The role of adjuvant medicinal therapies have beenwell debated but do have a conclusive outcome. Through this article, we want to highlight anddocument a case, which occurred at an exceptionally young age, at a site that had no predisposingfactors but has proven immunohistochemical diagnosis and was rapidly fulminating and aggressivelymalignant. The preoperative diagnosis of the patient was inconclusive reporting it to be amesenchymal tumor, therefore, the patient was treated with the intraoral approach for wide surgicalresection. The surgical specimen was subjected to immunohistochemistry with Vimentin stainingwhich reported it to be a Fibrosarcomas, therefore the patient was advised chemotherapy, yet theprognosis is guarded.
Highlights
Mesenchymal tumors have been extended overdiagnosed in past literature [1]
This article interests, as we report a case of Fibrosarcoma in the maxilla, without any predisposing etiopathology, at 6 years of age
According to SEERS a program of the National Cancer Institute, fibrosarcomas occurring in adults, accounts for 3.6% of all adult sarcomas, and depending upon the source, the patient’s sex may or may not play a role [7]
Summary
Mesenchymal tumors have been extended overdiagnosed in past literature [1]. The paradigm shift is credited to the advent of vimentin sensitive immunohistochemistry, which has become a gold standard for diagnosis of fibrosarcoma. Abstract- Fibrosarcomas are rare but highly fulminant and aggressively malignant neoplasm which occurs as a result of mutated spindle-shaped fibroblasts. Incidence of Fibrosarcoma in Maxilla accounts for less than 0.1%, when compared to other head and neck malignancies, and is predominantly found between 2nd to 6th decades of life.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
More From: International Journal of Medical Research & Review
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.