Abstract
Myofibroma, a rare neoplasm of spindle cells, consists of myofibroblasts and mainly occurs as a solitary lesion; however, some patients develop a multicentered process. An 18-year-old woman showed a gradual volume increase in the left jaw since 6 months prior. Clinical examination revealed a painless, hardened palpation, well-defined lesion. Incisional biopsy was performed, and the diagnosis of myofibroma was concluded. Immunohistochemistry showed low Ki-67 expression, negative S100, positive smooth muscle actin, and positive calponin. Panoramic radiography and computed tomography analyses showed radiolucent and hyperdense images, respectively, with bone and dental involvement. Surgical removal of the lesion was performed, with submandibular access and hemi-mandibular resection. Resection of the bone segment was performed with a safety margin of 1 cm, followed by fixation of a reconstruction plate to maintain facial contour and occlusion. Reconstruction with graft was planned as a second surgery.
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