Abstract
Now the phenomenon of synthropy is increasingly observed, when one patient is diagnosed with a conglomerate of diseases, each of which contributes to the realization of the clinical picture of the pathology, which often makes it difficult to diagnose it timely.The search and evaluation of epigenetic mechanisms, metabolic disturbances in monogenic pathology, clarification of their nature allow us to develop individual tactics of patient management, taking into account the revealed violations.The phenomenon of synthropy-the combination of the Hutchinson-Gilford syndrome with hyperhomocysteinemia, the lack of methylene tetrahydro-reductase, the violation of lipid metabolism and secondary mitochondrial dysfunction, is presented. The combination of childhood progeria with the lack of methylene tetrahydrofolate reductase, hyperhomocysteinemia, lipid and energy metabolism is an epigenetic pathology (C.D. Allis et all, 2010). The developed individual approach to the management of the patient from the position of epigenetic mechanisms underlying the development of the disease, performed correction of the revealed metabolic changes allowed to reduce the clinical manifestations of the disease, significantly improve the quality of life of the patient and family.
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