Abstract
Introduction: Carveol is a natural unsaturated, monocyclic monoterpenoid alcohol which is a constituent of spearmint essential oil. Earlier studies have shown that carveol has analgesic and anti-inflammatory actions in various in vivo studies. Currently, mechanisms of these effects are largely unknown. Objectives: The effects of carveol application on the functional properties of these receptors have been investigated. Materials and methods: cRNA encoding for homomeric human α 7-nicotinic acetylcholine (nACh) receptors were expressed in Xenopus oocytes. Ion currents mediated by the activation of nACh receptors were recorded using a two-electrode voltage clamp method. Results: Our results showed that carveol caused a significant inhibition of nACh receptor-mediated ion currents. The effect of carveol was reversible and gradually reached a steady-state level within 10 minutes of application time. Maximal amplitudes of currents activated by 100μM nACh were significantly inhibited by carveol in a concentration-dependent manner with an EC50 (half maximal effective concentration) value of 7.9μM. Conclusions: Our results indicate that carveol inhibits the function of human α 7-nACh receptors. Acknowledgements: Professor Murat Oz for supervising this project.
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