Abstract
Purpose: NFAT1 (NFATc2) is a member of the nuclear factor of activated T cells (NFAT/Nfat) family of transcription factors. Our recent studies revealed that mice with global deletion of NFAT1 (Nfat1-/- mice) exhibited normal skeletal development but displayed osteoarthritis (OA) as adults. NFAT1 deficiency-induced osteoarthritic phenotypes include articular cartilage lesion, chondro-osteophyte formation, subchondral bone thickening, and synovial hyperplasia with ectopic endochondral ossification.
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