Abstract
Approximately 95% of the population suffers at some point in their lifetime from acne vulgaris. Acne is a multifactorial disease of the pilosebaceous unit. This inflammatory skin disorder is most common in adolescents but also affects neonates, prepubescent children, and adults. Topical conventional systems are associated with various side effects. Novel drug delivery systems have been used to reduce the side effect of drugs commonly used in the topical treatment of acne. Topical treatment of acne with active pharmaceutical ingredients (API) makes direct contact with the target site before entering the systemic circulation which reduces the systemic side effect of the parenteral or oral administration of drug. The objective of the present review is to discuss the conventional delivery systems available for acne, their drawbacks, and limitations. The advantages, disadvantages, and outcome of using various carrier-based delivery systems like liposomes, niosomes, solid lipid nanoparticles, and so forth, are explained. This paper emphasizes approaches to overcome the drawbacks and limitations associated with the conventional system and the advances and application that are poised to further enhance the efficacy of topical acne formulations, offering the possibility of simplified dosing regimen that may improve treatment outcomes using novel delivery system.
Highlights
95% of the population suffers at some point in their lifetime from acne vulgaris [1]
Acne vulgaris can be defined as the most common skin disease, that results in comedos or severe inflammatory lesions in the face, back, and chest with a large number of sebaceous follicles, and the condition of the disease is associated with the elevated rate of sebum excretion [7]
The application of these novel delivery systems is advantageous to the skin as it distributes the topical agent gradually and in some cases has demonstrated the ability to reduce the irritancy of some antiacne drugs, yet it maintains a better efficacy when compared with conventional formulations [17]
Summary
95% of the population suffers at some point in their lifetime from acne vulgaris [1]. Acne is well known to respond to hormones, both endogenous and exogenous It is the most common dermatologic disorder affecting approximately 85% of the teenagers [2, 3] and a chronic inflammatory follicular disorder of the skin, occurring in specialized pilosebaceous units on the face consisting of the follicular canal with its rudimentary hair, and the group of sebaceous glands that surround and open on to the follicle [4,5,6]. The closed comedone (whitehead) and ripen comedone (blackhead) are the primary two noninflammatory lesions in acne. These lesions may progress to inflammatory papules and pustules when the contents rupture. The application of novel delivery systems to the skin distributes the topical agent gradually, reduces the irritancy of some antiacne drugs, and shows good efficacy [17]
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