Abstract
ABSTRACT This study focused on the detection of PMQR genes in enrofloxacin-resistant isolates from a pool of extended spectrum β-lactamase ESBL- producing Escherichia coli recovered from abattoir leachate. Leachates were collected from three designated points and analysed using the streak plate technique. Isolates were identified, and subjected to antibiotic susceptibility testing. Enrofloxacin-resistant isolates were selected for the detection of PMQR genes. Eight isolates showing resistance to enrofloxacin were obtained. The resistance to antibiotics in the eight isolates was: cefotaxime (100%), oxytetracycline (87.5%), trimethoprim-sulfamethoxazole (87.5%) and imipenem (0%). The eight enrofloxacin-resistant bacteria carried both qnrA and qnrS, 62.5% carried qnrB, 25% and 37.5% respectively carried qepA and oqxAB efflux pumps, and 50% carried aac(6’)-lb-cr. There was co-carriage of PMQR determinants in the eight enrofloxacin-resistant isolates. Occurrence of antibiotic resistance and carriage of resistance genes in bacteria from abattoir leachate is a budding public health challenge, hence urgent action must be taken on this.
Published Version
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