Abstract
BackgroundOne promising way of reducing caries is by using sucrose substitutes in food. rubusoside is a prototype sweet substance isolated from the leaves of the plant Rubrus suavissimus S. Lee. (Rosaceae), and is rated sweeter than sucrose. The purpose of this study was to investigate the effects of rubusoside on Streptococcus mutans growth, acidogenicity, and adherence to glass in vitro.MethodsThe effects of rubusoside on the growth and glass surface adhering of Streptococcus mutans were investigated by measuring the optical density of the culture at 540 nm with a spectrophotometer. Rubusoside influence on Streptococcus mutans acidogenicity was determined by measuring the pH of the culture. Sucrose, glucose, maltose, fructose and xylitol were designed to compare with rubusoside.ResultsS. mutans growth in the rubusoside-treated group was significantly lower than that in the sucrose, glucose, maltose and fructose groups (p < 0.05) except for xylitol group (p > 0.05). Sucrose-treated S. mutans exhibited the highest adherence to glass, and rubusoside-treated S. mutans exhibited the lowest. S. mutans adherence to a glass surface and acidogenicity with sucrose were significantly reduced by rubusoside.ConclusionsRubusoside may have some potential as a non-cariogenic, non-caloric sweetener.
Highlights
One promising way of reducing caries is by using sucrose substitutes in food. rubusoside is a prototype sweet substance isolated from the leaves of the plant Rubrus suavissimus S
The purpose of this study was to investigate the effects of Rubusoside on in vitro S. mutans cariogenic properties and to determine possibility to use as a non-cariogenic sugar substitute
Frequent and/or excessive sugar consumption has been described to play a central role in caries causation, and S. mutans appeared to play a key role in metabolizing sucrose to produce lactic acid, which can demineralize enamel [16]
Summary
One promising way of reducing caries is by using sucrose substitutes in food. rubusoside is a prototype sweet substance isolated from the leaves of the plant Rubrus suavissimus S. Dental caries is a multifactorial and chronic bacterial disease that involves the destruction of tooth hard tissue structure. It is directly caused by the acid produced by oral bacteria fermentation of dietary carbohydrates in dental plaque [1]. Subjects that frequently consume a considerable amount of fermentable carbohydrates, select for bacteria that ferment these carbohydrates and produce acids. This leads to more sugar fermentation and acid production, increasing the cariogenic bacteria even more. Acidogenic (acid-producing) and aciduric (acid-tolerating) bacteria such as the classic Streptococcus mutans, Streptococcus sobrinus and Lactobacillus spp., and the later discovered
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