Abstract
Erythritol is one of the most widely used low calorie sugar substitutes and has known inhibitory effects on the growth of Streptococcus mutans. However, the mechanism underlying this inhibition is poorly understood. Expression profiles of the glucosyltransferase (GTF) and fructosyltransferase (FTF) genes in S. mutans were evaluated in the presence of erythritol and other sweeteners. Adhesion of S. mutans to different carbohydrates was also determined across a range of concentrations. Erythritol significantly (p<0.05) inhibited adherence of S. mutans under multiple conditions, compared with sucrose. Erythritol significantly (p<0.05) inhibited expressions of gtfB, gtfC, gtfD, and ftf in the presence of various carbohydrates compared with sucrose. These findings were consistent with an anti-cariogenic effect of erythritol on S. mutans, and suggested mechanisms by which erythritol inhibits formation of dental caries.
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