Abstract
BackgroundIt is well established that patients with inflammatory joint diseases (IJD) have an increased cardiovascular (CV) mortality and morbidity. According to the 2016 EULAR recommendations on CV risk management, rheumatologists should ensure appropriate management of CV risk in rheumatoid arthritis (RA) and other IJDs. The aim was to assess the CV risk and CV disease in Middle-European patients with IJD.MethodsA retrospective chart review was performed for CV risk factors and CV disease in outpatients of a rheumatology outpatient clinic. CV risk was assessed according to the 2016 European Guidelines on CV disease prevention and also using 2 other approaches to compare the results with data from Norwegian and Spanish cohorts.ResultsOut of 432 patients, the prevalence of CV disease reached from 8.7% in spondyloarthritis (SpA) and 12.8% in psoriatic arthritis (PsA) to 18.7% in patients with RA. The number of CV risk factors did not differ between patients with RA, SpA, PsA, and non-inflammatory rheumatic disease (NIRD) (with 1.68 ± 0.13, 1.70 ± 0.13, 2.04 ± 0.16, and 1.78 ± 0.34, respectively). CV risk assessment could be performed in 82 patients after exclusion because of missing data and age. Stratification according to ESC guidelines showed low in 50%, moderate in 12.2%, high in 20.7%, and very high CV risk in 17.1% of patients aged between 40 and 65 years. CV risk in the Middle-European patients with IJD was higher than in the German general population (p = 0.004), and similar to the Norwegian patients with IJD, although patients with Middle-European PsA were at higher risk than the Norwegian patients (p = 0.045). Compared to the Spanish patients, Middle-European patients with IJD were more likely assigned to the high- to a very high-risk group (34.2 vs. 16.2%, p < 0.001), especially in RA disease (49.1 vs. 21%, respectively, p < 0.001).DiscussionHigh prevalence of established CV disease together with high CV risk in patients with IJD urges for increased vigilance for CV risk factors followed by appropriate interaction by the treating physicians. The prospective use of an international CV risk assessment tool will allow not only estimation of the individual CV risk but also provide data for direct comparisons with the general population and other international cohorts.
Highlights
Cardiovascular (CV) disease has to be considered as the main cause of mortality in the general population
The higher prevalence of traditional CV risk factors in patients with rheumatoid arthritis (RA) plays a major role in higher CV disease prevalence, the association between CV risk factors and a CV outcome seems to be weaker in patients with RA compared to the general population [7], indicating the presence of additional risk factors in inflammatory joint diseases (IJD), such as systemic inflammation
The CV risk was moderate in 12.2%, high in 20.7%, and very high in 17.1% of all patients with IJD aged between 40 and 65 years according to the ESC guidelines [11]
Summary
Cardiovascular (CV) disease has to be considered as the main cause of mortality in the general population. Other inflammatory joint diseases (IJD) like spondylarthritis (SpA) and psoriatic arthritis (PsA) may be linked to increased CV mortality and morbidity, as a large Canadian retrospective study reported a 36– 49% increase in vascular deaths in patients with SpA compared to the general population [6]. It is well established that patients with inflammatory joint diseases (IJD) have an increased cardiovascular (CV) mortality and morbidity. According to the 2016 EULAR recommendations on CV risk management, rheumatologists should ensure appropriate management of CV risk in rheumatoid arthritis (RA) and other IJDs. The aim was to assess the CV risk and CV disease in Middle-European patients with IJD
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