Abstract
Enhanced cardiovascular risk in rheumatoid arthritis: elucidation, assessment, and management.
Highlights
Janus kinases (JAK) contribute to cytokine production in rheumatoid arthritis (RA) [10] and are implicated in cardiovascular disease (CVD) [11]
This group of researchers has previously reported that gene polymorphisms located within the MHC region as well as variations of genes outside this region can contribute to CVD in RA [3, 4]
Besides our current insufficient understanding of CVD mechanisms, inconsistent traditional cardiovascular risk recording by treating physicians undoubtedly contributes to the reported lack of reduction in cardiovascular event rates over the past decades in RA [5]
Summary
Janus kinases (JAK) contribute to cytokine production in RA [10] and are implicated in CVD [11]. Bacani et al report that there is a 46% increased incidence in atrial fibrillation (AF) independent of traditional AF risk factors amongst RA patients, in a study that included 831 cases and controls. This again illustrates the potential role of nontraditional risk factors in the increased CVD risk associated with RA.
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