Abstract
Cardiovascular responses to isoflurane–nitrous oxide–oxygen anesthesia were studied in 32 older patients undergoing surgical operations. In half of the patients, anesthesia was induced with isoflurane alone, in the remainder, with isoflurane and thiopental All were intubated and mechanically ventilated to maintain normal Paco Stroke volume, heart rate, cardiac output, systemic resistance, systolic, diastolic and mean pressures, and central venous pressure changes were generally similar to those found by other investigators in patients not undergoing surgical operations, except that we observed an increased systemic resistance. A decrease in stroke volume was counterbalanced by increases in pulse rate and systemic resistance, so that the total effect on cardiac output and arterial pressures was negligible. The cardiovascular responses that we found suggest that isoflurane may counteract primary myocardial depression by autonomic mechanisms similar to those seen with diethyl ether anesthesia.
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