Abstract
2-Methyl-9-fluorocortisol was injected into intact rats in the absence of NaCl dietary supplements during 8 months. All animals became hypertensive and developed myocarditis, nephrosclerosis, and periarteritis nodosa. There were marked cardiac hypertrophy and arteriolosclerosis of the coronary arteries. Evaluation of the basic and maximum work capacity of the heart revealed that the myocardium was functionally equivalent in the control and treated animals. Consequently, sensitization by the intake of large amounts of NaCl is not indispensable for the production of hypertension and cardiovascular lesions with 2-methyl-9-fluorocortisol. In addition, as revealed by the cardiac function tests used, there is no strict parallelism between histologic and functional impairment of the heart.
Published Version
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