Abstract
Several studies have demonstrated that lower blood glucose concentrations are associated with reduced cardiovascular endpoints. The publication of intervention trials designed to investigate the impact of tighter glycaemic control on cardiovascular morbidity and mortality in type 2 diabetes have generally failed, individually, to generate statistically significant improvements in cardiovascular endpoints. This has spurred controversy regarding the role of glycaemic control within a multifactorial approach to treatment. However, a recent meta-analysis of these intervention trials showed that intensive glucose control improves cardiovascular outcomes.
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