Abstract
Previous studies on anaesthetized animals indicate that flesinoxan exerts hypotensive effects via stimulation of central 5-HT 1A receptors. The purpose of the present study was to investigate the cardiovascular and side effects of flesinoxan in conscious. renal hypertensive dogs at rest and during excrcise. Animals were pretrcated with prazosin (2.5 or 7.5 nmol/kg) to verify a reduction of dose-dependent side effects, as occurred in normotensive dogs. A decrease in blood pressure without reflex tachycardia was observed only with the lower dose of flesinoxan (0.1 μmol/kg). The higher dose (0.2 μmol/kg) led to an increase in blood pressure and heast rate. The increase in heart rate during exercise was diminished by 0.2 μmol/kg flesinoxan. Pretreatment with prazosin resulted in an additive hypotensive effect at rest. Side effects, occurring primarily after the higher dose of flesinoxan, were not influenced by prazosin. It is concluded that flcsinoxan is not likely to be efficacious in antihypcrtensive therapy.
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